黄芪为主药的中草药有助于化疗效果(US report)
纽约2月14日，2006年（路透社）报道 –以黄芪为基础的中药，显示出有增加铂化疗治疗晚期非小细胞肺癌的有效性的效果，这是根据Meta分析的34个随机试验2815病例所作出的判断。
研究人员在1月20日临床肿瘤学杂志解释道:“这项Meta分析的动机是研究大量试验黄芪为基础的中药结合铂为基础的化疗的疗效，因为传统的铂为基础的化疗标准化疗治疗晚期非小细胞肺癌癌症存在着药效低毒性大的缺点”.
对1305年“可能相关”的试验中, 研究人员随机选取了34个研究以试验晚期非小细胞肺癌患者给以中药含有中草药黄芪结合铂为基础的化疗或铂为基础的化疗。
文章第一作者 Michael McCulloch，加州大学伯克利分校的流行病学博士生告诉路透社记者: “ 12个研究（ 940病例）的报告说，中药材减少患者在12个月死亡的危险大约有三分之一”. 他说:“在另两项研究（ 221病例），中药配方制剂减少死亡的危险在24个月达近一半，并在另外四个研究（ 257病例），中药配方注射制剂稳定和改善病人进行日常工作的能力达28 ％ “.
但麦卡洛克提醒人们:这些结果只能提供中草药结合铂为基础的化疗有效性的初步证据.在它们可能被用于医疗实践以前, 这些结果需要更加严格控制的试验的证实. 他补充说:“我们希望，我们的研究将刺激人们继续关注研究结合中药治疗与传统疗法的癌症患者潜在好处”
消息来源：临床肿瘤学杂志2006 ; 24:419-430 。
Astragalus (黄芪)-Based Chinese Herbs May Boost Chemotherapy's Punch By Megan Rauscher
http://www.cancerpage.com/news/article.asp?id=9394
NEW YORK FEB 14, 2006 (Reuters Health) - Astragalus-based Chinese herbs appear to augment the effectiveness of platinum-based chemotherapy for advanced non-small-cell lung cancer, according to a meta-analysis of 34 randomized trials representing 2,815 patients.
"This meta-analysis was motivated by a large number of published trials of Astragalus-based Chinese herbal medicines combined with platinum-based chemotherapy, and the continuing problems of low efficacy and high toxicity in standard chemotherapy treatment of advanced non-small-cell lung cancer," explain investigators in the January 20th Journal of Clinical Oncology.
Of 1,305 "potentially relevant" publications, researchers selected 34 in which advanced non-small-cell lung cancer patients were randomized to Chinese herbal medicine containing the herb Astragalus in combination with platinum-based chemotherapy or platinum-based chemotherapy alone.
"Twelve studies (940 patients) reported that Chinese herbal medicines reduced the risk of death at 12 months by roughly one-third," Michael McCulloch, a doctoral student in epidemiology at the University of California, Berkeley, and lead author of the paper told Reuters Health.
"In another two studies (221 patients), herbal formula Jin Fu Kang reduced the risk of death at 24 months by nearly half and in another four studies (257 patients), herbal formula Ai Di injection stabilized or improved patient's ability to conduct everyday tasks by 28%," he said.
McCulloch cautioned, however, that these results "provide only preliminary evidence for the effectiveness of Chinese herbal medicines in combination with platinum-based chemotherapy."
Prior to being incorporated into practice, these results require confirmation with rigorously controlled trials, he added.
"We hope that our study will stimulate continued interest in researching the potential benefits of combining Chinese herbal therapy with conventional therapies for people with cancer," McCulloch said.
SOURCE: J Clin Oncol 2006;24:419-430.
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